Beside for intercellular route (Cevc 2004, tang et

Beside SC, tight junction proteins (claudin, occluding and zonula
occludins-1) have been implicated for providing barrier function to skin . Other
than barrier like property of skin outside, there are many factors which affect
the delivery of the drug and they are discussed in the following section. FACTORS AFFECTING NANO BASED
TRANSDERMAL DRUG DELIVERY

SYSTEM

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PARTICLE SIZE and Shape

The nanodrugs transdermal delivery is affected by its size and shape which further decide physical steadiness
and their cellular uptake (Escobar Chavez et al 2012). Nanoformulations can be
delivered concurrently using different means/routes owing to their particle
size and physicochemical properties (Borali 2010). Skin anatomical features
only allows free distribution of particles 3-10 µm for transfollicular route. Particles of smaller size
are preferred since they make available larger surface area hence can have high
drug loading capacity. Attama et al (2007) reported that low particle size solid lipid
nanodispersions  (SLN) are
more stable and well accepted in vivo and active formulkation had high drug
concentration. Maestrelli et al (2009), who investigated ethosomes prepared by different
techniques made similar conclusions and found that small unilamellar vesicles
(SUVs) drug efficacy of benzocaine (BZC) was owing to its small size, higher
surface area which led to more intimate contact with the epithelium for longer
duration of time for therapeutic action. Desai
et al. (2010) and Baroli (2010) concluded that lipophilic nanoparticles have
high partition coefficient and drugs having molecular weight

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